Genotropin Miniquick

Generic Name: somatropin (soe ma TROE pin)

Brand Names: Genotropin, Genotropin Miniquick, Humatrope, Norditropin, Norditropin Cartridge, Norditropin FlexPro Pen, Norditropin Nordiflex Pen, Nutropin, Nutropin AQ, Omnitrope, Saizen, Serostim, Tev-tropin, Zorbtive

What is Genotropin Miniquick (somatropin)?

Somatropin is a form of human growth hormone. Human growth hormone is important in the body for the growth of bones and muscles.

Somatropin is used to treat growth failure in children and adults who lack natural growth hormone, and in those with chronic kidney failure, Noonan syndrome, Turner syndrome, Prader-Willi syndrome, short stature at birth with no catch-up growth, and other causes. Somatropin is also used to prevent severe weight loss in people with AIDS, or to treat short bowel syndrome.

Somatropin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Genotropin Miniquick (somatropin)?

Before you receive somatropin, tell your doctor about all your past and present medical conditions, especially allergies, trauma, surgery, diabetes, cancer, breathing problems, liver or kidney disease, scoliosis, high blood pressure, pancreas disorder, underactive thyroid, or a brain tumor.

Also tell your doctor about all other medications you use, especially steroids or diabetes medications. Your dosages of these medicines may need to be changed when you start using somatropin. Do not stop using a steroid suddenly or change any of your medication doses without your doctor's advice.

If you have Prader-Willi syndrome and are using somatropin, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring.

Call your doctor at once if you have sudden and severe pain in your upper stomach with nausea and vomiting, fast heartbeat, increased thirst or urination, weight loss, or vision changes and sudden, severe pain behind your eyes.

What should I discuss with my healthcare provider before using Genotropin Miniquick (somatropin)?

Before you receive somatropin, tell your doctor if you have ever had an allergic reaction to a growth hormone medicine, or to drug preservatives such as benzyl alcohol, metacresol or glycerin. You should not use this medication if you are allergic to somatropin, or if you have:

• 
  

  diabetic retinopathy (a serious eye condition caused by diabetes);

  
  


• 
  

  cancer; or

  
  


• 
  

  Prader-Willi syndrome and are also overweight or have sleep apnea or severe respiratory (lung) problems.

  
  

You should also not use somatropin if you have a serious medical condition after having:

• 
  

  open heart surgery or stomach surgery;

  
  


• 
  

  trauma or other medical emergency; or

  
  


• 
  

  breathing problems (such as lung failure).

  
  

To make sure you can safely take somatropin, tell your doctor if you have any of these other conditions:

• 
  

  liver disease;

  
  


• 
  

  kidney disease (or if you are on dialysis);

  
  


• 
  

  diabetes;

  
  


• 
  

  a pituitary gland disorder;

  
  


• 
  

  scoliosis;

  
  


• 
  

  high blood pressure (hypertension);

  
  


• 
  

  a pancreas disorder (especially in children);

  
  


• 
  

  a history of cancer;

  
  


• 
  

  carpal tunnel syndrome;

  
  


• 
  

  underactive thyroid; or

  
  


• 
  

  a brain tumor or lesion.

  
  

FDA pregnancy category B. Some brands of somatropin are not expected to harm an unborn baby, including Genotropin, Omnitrope, Saizen, Serostim, and Zorbtive. FDA pregnancy category C. It is not known whether certain other brands of somatropin will harm an unborn baby, including Humatrope, Norditropin, Nutropin, and Tev-tropin. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether somatropin passes into breast milk or if it could harm a nursing baby. Do not use somatropin without telling your doctor if you are breast-feeding a baby.

How should I use Genotropin Miniquick (somatropin)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your dose and brand of somatropin, and how often you give it will depend on what you are being treated for. Follow the directions on your prescription label.

Somatropin is injected into a muscle or under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Use a different place on your body each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row. Do not inject this medicine into skin or muscle that is red, sore, infected, or injured.

Do not shake the medication bottle or you may ruin the medicine. When mixing somatropin with a diluent (liquid), use a gentle swirling motion. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure this medication is helping your condition and not causing harm, your blood and growth progress will need to be tested often. Your eyes may also need to be checked. Visit your doctor regularly.

If you are being treated for short bowel syndrome, follow the diet plan created for you by your doctor or nutrition counselor to help control your condition. Somatropin is not a cure for short bowel syndrome.

If you use a form of somatropin that comes in a cartridge for use with an injection pen, use only the pen injection system provided with the somatropin brand you use.

How you store this medicine will depend on what brand you are using and what diluent you are mixing somatropin with. After mixing somatropin, you may need to use it right away or you may be able to store it for later use. Read and carefully follow the instructions provided with your medicine about proper storage of somatropin before and after it has been mixed. Ask your pharmacist if you have any questions about proper storage of your medication.

Throw away any somatropin left over after the expiration date on the label has passed.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Call your doctor if you miss more than 3 doses in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause tremors or shaking, cold sweats, increased hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, and nausea. Long-term overdose may cause excessive growth.

What should I avoid while using Genotropin Miniquick (somatropin)?

If you use Zorbtive to treat short bowel syndrome, avoid drinking fruit juices or soda beverages. Follow the instructions of your doctor or nutrition counselor about what types of liquids you should drink while using Zorbtive.

Avoid drinking alcohol if you have short bowel syndrome. Alcohol can irritate your stomach and could make your condition worse.

Genotropin Miniquick (somatropin) side effects

If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have occurred in patients with Prader-Willi syndrome who use somatropin.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

  
  


• 
  

  increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss;

  
  


• 
  

  sudden and severe pain behind your eyes, vision changes;

  
  


• 
  

  swelling in your head, face, hands, or feet; or

  
  


• 
  

  numbness or tingling in your wrist, hand, or fingers.

  
  

Less serious side effects may include:

• 
  

  headache, feeling tired;

  
  


• 
  

  redness, soreness, swelling, rash, itching, pain, or bruising where the medicine was injected;

  
  


• 
  

  pain in your arms or legs, joint stiffness or pain;

  
  


• 
  

  muscle pain; or

  
  


• 
  

  cold symptoms such as stuffy nose, sneezing, sore throat.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Genotropin Miniquick (somatropin)?

Before using somatropin, tell your doctor if you use insulin or take oral (by mouth) medicine to treat diabetes. Somatropin may affect blood sugar levels and you may need to adjust your dose of the diabetes medication. Do not change the dose of your diabetes medication without your doctor's advice.

Tell your doctor if you use any type of steroid medicine such as cortisone, dexamethasone, methylprednisolone, prednisone, and others. Steroids can make somatropin less effective and your doses may need to be adjusted. Do not stop using a steroid suddenly. Follow your doctor's instructions.

Tell your doctor about all other medications you use, especially cyclosporine (Gengraf, Neoral, Sandimmune), seizure medication, birth control pills, anabolic steroids, or hormone replacement medications for men or women.

This list is not complete and other drugs may interact with somatropin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Genotropin Miniquick resources

• Genotropin Miniquick Side Effects (in more detail)
• Genotropin Miniquick Use in Pregnancy & Breastfeeding
• Genotropin Miniquick Drug Interactions
• Genotropin Miniquick Support Group
• 0 Reviews for Genotropin Miniquick - Add your own review/rating

• Genotropin Miniquick Advanced Consumer (Micromedex) - Includes Dosage Information


• Somatropin Professional Patient Advice (Wolters Kluwer)


• Genotropin Prescribing Information (FDA)


• Genotropin MedFacts Consumer Leaflet (Wolters Kluwer)


• Humatrope Cartridge MedFacts Consumer Leaflet (Wolters Kluwer)


• Humatrope Prescribing Information (FDA)


• Norditropin MedFacts Consumer Leaflet (Wolters Kluwer)


• Norditropin Prescribing Information (FDA)


• Nutropin Prescribing Information (FDA)


• Nutropin Subcutaneous, Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Nutropin MedFacts Consumer Leaflet (Wolters Kluwer)


• Nutropin AQ Prescribing Information (FDA)


• Nutropin AQ MedFacts Consumer Leaflet (Wolters Kluwer)


• Nutropin Depot Prescribing Information (FDA)


• Omnitrope Prescribing Information (FDA)


• Omnitrope MedFacts Consumer Leaflet (Wolters Kluwer)


• Omnitrope Consumer Overview


• Saizen Prescribing Information (FDA)


• Saizen MedFacts Consumer Leaflet (Wolters Kluwer)


• Serostim Prescribing Information (FDA)


• Serostim MedFacts Consumer Leaflet (Wolters Kluwer)


• Tev-Tropin MedFacts Consumer Leaflet (Wolters Kluwer)


• Tev-Tropin Prescribing Information (FDA)


• Zorbtive Prescribing Information (FDA)


• Zorbtive MedFacts Consumer Leaflet (Wolters Kluwer)


• Zorbtive Consumer Overview

Compare Genotropin Miniquick with other medications

• Adult Human Growth Hormone Deficiency
• Hypopituitarism
• Pediatric Growth Hormone Deficiency
• Short Stature for Age
• Turner's Syndrome

Where can I get more information?

• Your pharmacist can provide more information about somatropin.

See also: Genotropin Miniquick side effects (in more detail)

Gilchew IR Chewable Tablets

Pronunciation: fehn-ihl-EFF-rihn
Generic Name: Phenylephrine
Brand Name: AH-Chew D and Gilchew IR

Gilchew IR Chewable Tablets are used for:

Relieving congestion due to colds, flu, hay fever, and other allergies. It may also be used for other conditions as determined by your doctor.

Gilchew IR Chewable Tablets are a decongestant. It works by shrinking swollen and congested nasal tissues (mucous membranes) by constricting blood vessels. This results in relief of congestion (stuffy feeling) and improved drainage of mucus and improved breathing through the nose.

Do NOT use Gilchew IR Chewable Tablets if:

• you are allergic to any ingredient in Gilchew IR Chewable Tablets


• you are taking furazolidone or have taken a monoamine oxidase (MAO) inhibitor (eg, phenelzine) in the last 14 days


• you have high blood pressure or an abnormally fast heartbeat

Contact your doctor or health care provider right away if any of these apply to you.

Before using Gilchew IR Chewable Tablets:

Some medical conditions may interact with Gilchew IR Chewable Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, plan to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have heart disease, diabetes, phenylketonuria (PKU), tumors on your adrenal gland, or thyroid disease

Some MEDICINES MAY INTERACT with Gilchew IR Chewable Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Rauwolfia derivatives (eg, reserpine) or tricyclic antidepressants (eg, amitriptyline) because the effectiveness of Gilchew IR Chewable Tablets may be decreased


• Cocaine, furazolidone, methyldopa, MAO inhibitors (eg, phenelzine), oxytocic medicines (eg, oxytocin), rauwolfia derivatives (eg, reserpine), or tricyclic antidepressants (eg, amitriptyline) because the actions and side effects of Gilchew IR Chewable Tablets may be increased


• Bromocriptine, COMT inhibitors (eg, entacapone), cocaine, or droxidopa because the actions and side effects of these medicines may be increased


• Guanethidine because its effectiveness may be decreased by Gilchew IR Chewable Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Gilchew IR Chewable Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Gilchew IR Chewable Tablets:

Use Gilchew IR Chewable Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Gilchew IR Chewable Tablets with food, water, or milk to minimize stomach irritation.


• Chew thoroughly before swallowing. Tablets may be broken in half to make them easier to take.


• If you miss a dose of Gilchew IR Chewable Tablets and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Gilchew IR Chewable Tablets.

Important safety information:

• Gilchew IR Chewable Tablets may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Gilchew IR Chewable Tablets. Using Gilchew IR Chewable Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Do not take diet or appetite control medicines while you are taking Gilchew IR Chewable Tablets.


• If your symptoms do not improve within 7 days or if you develop a high fever, check with your doctor.


• If you have trouble sleeping, ask your pharmacist or doctor about the best time to take Gilchew IR Chewable Tablets


• Phenylketonuria patients - Gilchew IR Chewable Tablets contains phenylalanine.


• Diabetes patients - Gilchew IR Chewable Tablets may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.


• Use Gilchew IR Chewable Tablets with caution in the ELDERLY because they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Gilchew IR Chewable Tablets during pregnancy. It is unknown if Gilchew IR Chewable Tablets are excreted in breast milk. If you are or will be breast-feeding while you are using Gilchew IR Chewable Tablets, check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, some people develop a need to continue taking Gilchew IR Chewable Tablets. This is known as DEPENDENCE or "addiction." If you are addicted and you suddenly stop taking Gilchew IR Chewable Tablets, you may experience WITHDRAWAL symptoms, including depression.

Possible side effects of Gilchew IR Chewable Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Difficulty urinating; dizziness; headache; nausea; nervousness; restlessness; sleeplessness; stomach irritation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Gilchew IR side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; hallucinations; irregular or unusually slow or rapid heartbeat; rapid breathing; seizures.

Proper storage of Gilchew IR Chewable Tablets:

Store Gilchew IR Chewable Tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Gilchew IR Chewable Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Gilchew IR Chewable Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Gilchew IR Chewable Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Gilchew IR Chewable Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Gilchew IR resources

• Gilchew IR Side Effects (in more detail)
• Gilchew IR Use in Pregnancy & Breastfeeding
• Gilchew IR Drug Interactions
• Gilchew IR Support Group
• 0 Reviews for Gilchew IR - Add your own review/rating

Compare Gilchew IR with other medications

• Hypotension
• Nasal Congestion
• Shock
• Supraventricular Tachycardia

Gentak Drops

Pronunciation: jen-ta-MYE-sin
Generic Name: Gentamicin
Brand Name: Examples include Gentasol and Gentak

Gentak Drops are used for:

Treating surface eye infections caused by certain bacteria. It may also be used for other conditions as determined by your doctor.

Gentak Drops are a topical antibiotic. It works by slowing the growth of, or killing, sensitive bacteria.

Do NOT use Gentak Drops if:

• you are allergic to any ingredient in Gentak Drops

Contact your doctor or health care provider right away if any of these apply to you.

Before using Gentak Drops:

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Gentak Drops. Because little, if any, of Gentak Drops are absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Gentak Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Gentak Drops:

Use Gentak Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Gentak Drops are for use in the eye. Avoid contact with other mucous membranes.


• Soft contact lenses may absorb a chemical in Gentak Drops. Do not wear contact lenses while you are using Gentak Drops. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.


• To use Gentak Drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.


• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.


• To clear up your infection completely, use Gentak Drops for the full course of treatment. Keep using it even if you feel better in a few days.


• Using Gentak Drops at the same times each day will help you to remember to use it.


• If you miss a dose of Gentak Drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Gentak Drops.

Important safety information:

• Gentak Drops may cause blurred vision. Use Gentak Drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Gentak Drops may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.


• Be sure to use Gentak Drops for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Gentak Drops may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Do not use Gentak Drops for future eye problems without checking with your doctor.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Gentak Drops while you are pregnant. If you are or will be breast-feeding while you use Gentak Drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Gentak Drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloodshot eye; burning or stinging of the eye.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); delayed healing of the cornea; hallucinations; redness, itching or swelling of the eyelids; ulcers of the cornea.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Gentak side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Gentak Drops:

Store Gentak Drops at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, light, and moisture. Do not freeze. Keep Gentak Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Gentak Drops, please talk with your doctor, pharmacist, or other health care provider.


• Gentak Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Gentak Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Gentak resources

• Gentak Side Effects (in more detail)
• Gentak Use in Pregnancy & Breastfeeding
• Gentak Support Group
• 0 Reviews for Gentak - Add your own review/rating

Compare Gentak with other medications

• Conjunctivitis, Bacterial

Geone Oral

Generic Name: butalbital, acetaminophen, and caffeine (Oral route)

bue-TAL-bi-tal, a-seet-a-MIN-oh-fen, KAF-een

Oral route(Tablet)

Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 mg/day, and often involve more the one acetaminophen-containing product

Commonly used brand name(s)

In the U.S.

• Anolor 300


• Dolgic LQ


• Esgic


• Esgic-Plus


• Ezol


• Fioricet


• Geone


• Margesic


• Medigesic


• Nonbac


• Pacaps


• Repan

Available Dosage Forms:

• Capsule


• Tablet


• Solution

Therapeutic Class: Butalbital/Acetaminophen Combination

Pharmacologic Class: Barbiturate

Chemical Class: Methylxanthine

Uses For Geone

Butalbital, acetaminophen, and caffeine combination is used to relieve symptoms of tension (or muscle contraction) headaches.

Butalbital belongs to the group of medicines called barbiturates. Barbiturates act in the central nervous system (CNS) to produce their effects.

Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage.

When butalbital is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

Caffeine is a CNS stimulant that is used with pain relievers to increase their effect. It has also been used for migraine headaches. However, caffeine can also cause physical dependence when it is used for a long time. This may lead to withdrawal (rebound) headaches when you stop taking it.

This medicine is available only with your doctor's prescription.

Before Using Geone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of butalbital, acetaminophen, and caffeine combination in children younger than 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of butalbital, acetaminophen, and caffeine combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving butalbital, acetaminophen, and caffeine combination.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adinazolam


• Alfentanil


• Alprazolam


• Amobarbital


• Anileridine


• Anisindione


• Aprobarbital


• Bromazepam


• Brotizolam


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlordiazepoxide


• Chlorzoxazone


• Clobazam


• Clonazepam


• Clorazepate


• Codeine


• Dantrolene


• Diazepam


• Dicumarol


• Estazolam


• Ethchlorvynol


• Fentanyl


• Flunitrazepam


• Flurazepam


• Halazepam


• Hydrocodone


• Hydromorphone


• Ketazolam


• Levorphanol


• Lorazepam


• Lormetazepam


• Medazepam


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Midazolam


• Morphine


• Morphine Sulfate Liposome


• Nitrazepam


• Nordazepam


• Oxazepam


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenindione


• Phenobarbital


• Phenprocoumon


• Prazepam


• Primidone


• Propoxyphene


• Quazepam


• Quetiapine


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Temazepam


• Thiopental


• Triazolam

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol


• Cannabis


• Carbamazepine


• Imipramine


• Isoniazid


• Phenytoin


• Prednisone


• Warfarin


• Zidovudine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Cabbage


• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse, history of or


• Drug dependence, or history of or


• Weakened physical condition—Use with caution. May increase risk for more serious side effects.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Porphyria (an enzyme problem)—Should not be used in patients with this condition.

• Stomach problems—Use with caution. May make these conditions worse.

Proper Use of butalbital, acetaminophen, and caffeine

This section provides information on the proper use of a number of products that contain butalbital, acetaminophen, and caffeine. It may not be specific to Geone. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming and cause mental or physical dependence. Also, large amounts of acetaminophen may cause liver damage if taken for a long time.

Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For tension headaches:
    
    • Adults, teenagers, and children 12 years of age—One or two tablets every 4 hours as needed. However, the dose is usually not more than 6 tablets per day. Do not exceed 4 grams (4000 milligrams) of acetaminophen (Tylenol (R)) per day.
    
    
    • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Geone

It is very important that your doctor check your progress while you or your child are taking this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

This medicine may be habit-forming. If you or your child feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop using this medicine and call your doctor right away if you or your child have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

This medicine may make you dizzy or drowsy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Also, there may be a greater risk of liver damage if you drink three or more alcoholic beverages while you are taking acetaminophen. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine.

Before you have any medical tests, tell the medical doctor in charge that you or your child are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Geone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Lightheadedness


• shortness of breath

Incidence not known

• Abdominal or stomach pain


• black, tarry stools


• bleeding gums


• blistering, peeling, or loosening of the skin


• blood in the urine or stools


• blurred vision


• change in the frequency of urination or amount of urine


• chills


• cough


• diarrhea


• difficulty with breathing


• difficulty with swallowing


• dizziness


• drowsiness


• dry mouth


• fainting


• fast heartbeat


• fast, pounding, or irregular heartbeat or pulse


• flushed or dry skin


• fruit-like breath odor


• hives


• increased hunger


• increased thirst


• increased urination


• itching


• joint or muscle pain


• loss of appetite


• nausea or vomiting


• pinpoint red spots on the skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red skin lesions, often with a purple center


• red, irritated eyes


• seizure


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• skin rash


• sore throat


• sores, ulcers, or white spots in the mouth or on the lips


• sweating


• swelling of the feet or lower legs


• tightness in the chest


• trembling or shaking of the hands or feet


• troubled breathing


• unexplained weight loss


• unusual bleeding or bruising


• unusual tiredness or weakness


• weakness


• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Confusion as to time, place, or person


• dark urine


• difficult or painful urination


• difficult or troubled breathing


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• fever


• general feeling of discomfort or illness


• hallucinations


• headache


• holding false beliefs that cannot be changed by fact


• increased sweating


• irregular, fast or slow, or shallow breathing


• light-colored stools


• loss of appetite


• pale or blue lips, fingernails, or skin


• restlessness


• sleeplessness


• sudden decrease in the amount of urine


• sweating


• trouble sleeping


• unable to sleep


• unpleasant breath odor


• unusual excitement, nervousness, or restlessness


• vomiting of blood


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Relaxed and calm


• sleepiness

Incidence not known

• Anxiety


• bloated


• constipation


• continuing ringing or buzzing or other unexplained noise in the ears


• depression


• earache


• excess air or gas in the stomach or intestines


• false or unusual sense of well-being


• full feeling


• hearing loss


• heartburn


• heavy eyelids


• high energy


• hot spells


• hyperventilation


• irritability


• numbness


• pain in the leg


• passing gas


• sluggishness


• stuffy nose


• tingling sensation

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Gentex LQ

Generic Name: carbetapentane, guaifenesin, and phenylephrine (kar BET a PEN tane, gwye FEN e sin, and FEN il EFF rin)

Brand Names: Carbetaplex, MonteCough

What is Gentex LQ (carbetapentane, guaifenesin, and phenylephrine)?

Carbetapentane is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of carbetapentane, guaifenesin, and phenylephrine is used to treat stuffy nose, sinus congestion, cough, and chest congestion caused by sinusitus, bronchitis, or the common cold or flu.

Carbetapentane, guaifenesin, and phenylephrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Gentex LQ (carbetapentane, guaifenesin, and phenylephrine)?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. You should not use this medication if you have severe high blood pressure, severe colitis or toxic megacolon, or if you are unable to urinate. Do not use cough and cold medicine if you have untreated or uncontrolled diseases such as high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

What should I discuss with my healthcare provider before taking Gentex LQ (carbetapentane, guaifenesin, and phenylephrine)?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you have severe constipation, severe colitis or toxic megacolon, or if you are unable to urinate. Do not use cough and cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have ever had:

• 
  

  glaucoma;

  
  


• 
  

  asthma or COPD;

  
  


• 
  

  diabetes;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  cough with mucus, or cough caused by emphysema or chronic bronchitis;

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  an adrenal gland tumor or disorder (such as pheochromocytoma or Addison's disease); or

  
  


• 
  

  if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

  
  

FDA pregnancy category C. It is not known whether carbetapentane, guaifenesin, and phenylephrine will harm an unborn baby. Do not use cold or cough medicine without medical advice if you are pregnant. This medicine may pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using carbetapentane, guaifenesin, and phenylephrine.

Artificially sweetened liquid cough or cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.

How should I take Gentex LQ (carbetapentane, guaifenesin, and phenylephrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days. Store at room temperature away from moisture, heat, and light. Do not freeze.

What happens if I miss a dose?

Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme dizziness or restless feeling, severe stomach pain, vomiting, diarrhea, loss of appetite, rapid heart rate, flushing (warmth, redness, or tingly feeling).

What should I avoid while taking Gentex LQ (carbetapentane, guaifenesin, and phenylephrine)?

This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Drinking alcohol can increase certain side effects of carbetapentane, guaifenesin, and phenylephrine. Avoid becoming overheated or dehydrated during exercise and in hot weather. Carbetapentane, guaifenesin, and phenylephrine can decrease sweating and you may be more prone to heat stroke. Ask a doctor or pharmacist before using any other cold, allergy, cough, or sleep medicine. Antihistamines, decongestants, and cough suppressants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, decongestant, or cough suppressant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Gentex LQ (carbetapentane, guaifenesin, and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using carbetapentane, guaifenesin, and phenylephrine and call your doctor at once if you have a serious side effect such as:

• 
  

  fast or pounding heartbeats;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  dizziness, drowsiness, headache, weakness;

  
  


• 
  

  dry mouth, nose, or throat, increased sweating or urination;

  
  


• 
  

  nausea, mild stomach pain;

  
  


• 
  

  sleep problems (insomnia); or

  
  


• 
  

  feeling restless or excited (especially in children).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Gentex LQ (carbetapentane, guaifenesin, and phenylephrine)?

Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by brompheniramine.

Ask a doctor or pharmacist if it is safe for you to take carbetapentane, guaifenesin, and phenylephrine if you are also using any of the following drugs:

• 
  

  an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan, Silenor), nortriptyline (Pamelor), and others; or

  
  


• 
  

  heart or blood pressure medication such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), mecamylamine (Inversine), methyldopa (Aldomet), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), reserpine, sotalol (Betapace), and others.

  
  

This list is not complete and other drugs may interact with carbetapentane, guaifenesin, and phenylephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Gentex LQ resources

• Gentex LQ Side Effects (in more detail)
• Gentex LQ Use in Pregnancy & Breastfeeding
• Gentex LQ Drug Interactions
• Gentex LQ Support Group
• 0 Reviews for Gentex LQ - Add your own review/rating

• Aquatab C MedFacts Consumer Leaflet (Wolters Kluwer)


• Carbatab-12 Sustained-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Carbetapentane/Guaifenesin/Phenylephrine Solution MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Gentex LQ with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about carbetapentane, guaifenesin, and phenylephrine.

See also: Gentex LQ side effects (in more detail)

Gentamicin Sulfate eent

Class: Antibacterials
VA Class: AM300
CAS Number: 1405-41-0
Brands: Gentak, Pred-G

Introduction

Antibacterial; aminoglycoside antibiotic produced by Micromonospora purpurea.^{a b c d e}

Uses for Gentamicin Sulfate

Bacterial Ophthalmic Infections

Treatment of superficial infections of the eye caused by susceptible bacteria.^{a b c}

Used alone or in fixed combination with a topical corticosteroid (e.g., prednisolone) when such combination therapy is indicated.^{d e} (See Use of Fixed Combinations Containing Corticosteroids under Cautions.)

Gentamicin Sulfate Dosage and Administration

Administration

Ophthalmic Administration

Apply topically to the eye(s) as an ophthalmic solution, suspension, or ointment.^{a b c d e}

Not for injection into the eye; do not inject subconjunctivally or instill directly into the anterior chamber of the eye.^{a b c d}

Avoid contamination of the tip of the container.^{102 c d e}

Shake suspension well prior to use.^d

Dosage

Available as gentamicin sulfate and as fixed combinations containing prednisolone acetate; dosage expressed in terms of gentamicin.^{b c d e}

Pediatric Patients

Bacterial Ophthalmic Infections

Gentamicin Sulfate 0.3%

Ophthalmic Solution

Infants and children >1 month of age: 1 or 2 drops into the affected eye(s) every 4 hours.^c

Infants and children >1 month of age: For severe infections, instill up to 2 drops into the affected eye(s) every hour.^c

Ophthalmic Ointment

Infants and children >1 month of age: Apply a 1.25-cm ribbon to the affected eye(s) 2 or 3 times daily.^b

Adults

Bacterial Ophthalmic Infections

Gentamicin Sulfate 0.3%

Ophthalmic Solution

1 or 2 drops into the affected eye(s) every 4 hours.^c

Severe infections: Instill up to 2 drops into the affected eye(s) every hour.^c

Ophthalmic Ointment

Apply a 1.25-cm ribbon to the affected eye(s) 2 or 3 times daily.^b

Gentamicin Sulfate 0.3% and Prednisolone Acetate 0.6%

If improvement does not occur after 2 days, reevaluate the patient.^{d e}

Do not discontinue therapy prematurely.^{d e}

Ophthalmic Solution

Initial 24–48 hours, up to 1 drop into the conjunctival sac of the affected eye(s) every hour; thereafter, 1 drop 2–4 times daily.^d

Ophthalmic Ointment

Apply a 1.25-cm ribbon into the conjunctival sac of the affected eye(s) 1–3 times daily.^e

Cautions for Gentamicin Sulfate

Contraindications

• 
  

  Known hypersensitivity to gentamicin or any ingredient in the formulation.^{a b c d e}

  
  

Warnings/Precautions

Sensitivity Reactions

Sensitization may occur.^{a b c d e} Discontinue if hypersensitivity reaction occurs.^{a b c}

Commercially available gentamicin preparations contain other ingredients (e.g., parabens), which may cause allergic contact dermatitis.^a (See Preparations.)

Cross-allergenicity

Cross-allergenicity occurs among the aminoglycosides.^a

General Precautions

Superinfection

Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi.^{a b c d e} If superinfection occurs, discontinue drug and institute appropriate therapy.^a

Use of Fixed Combinations Containing Corticosteroids

Topical corticosteroids may mask clinical signs of bacterial, fungal, or viral infections or may suppress hypersensitivity reactions to gentamicin or other ingredients in the formulation.^a

When gentamicin is used in fixed combination with a corticosteroid, consider the cautions, precautions, and contraindications associated with EENT corticosteroids.^{a d e}

Infection Complications

Ophthalmic ointments may delay corneal healing.^b

Bacterial and fungal corneal ulcers possible during treatment.^{b c}

Specific Populations

Pregnancy

Category C.^{b c d e}

Lactation

Systemic gentamicin is distributed into breast milk.^g Gentamicin in fixed combination with prednisolone acetate (ophthalmic suspension and ophthalmic ointment): Discontinue nursing or the drug.^{d e}

Pediatric Use

Safety and efficacy of gentamicin ophthalmic solution and ophthalmic ointment not established in neonates.^{b c}

Safety and efficacy of gentamicin in fixed combination with prednisolone acetate (ophthalmic suspension and ophthalmic ointment) not established.^{d e}

Geriatric Use

Gentamicin in fixed combination with prednisolone acetate (ophthalmic suspension and ophthalmic ointment): No substantial differences in safety or efficacy relative to younger patients.^{d e}

Common Adverse Effects

Transient irritation, burning, stinging.^{a b c d}

Gentamicin Sulfate Pharmacokinetics

Absorption

Extent

Absorption is greatest when the cornea is abraded.^a

Distribution

Extent

Systemic gentamicin crosses the placenta and is distributed into breast milk.^g

Stability

Storage

Ophthalmic

Ointment

Gentamicin: 2–30°C.^b

Gentamicin in fixed combination with prednisolone acetate: 15–25°C.^e

Solution

Gentamicin: 2–30°C; avoid excessive heat.^c

Suspension

Gentamicin in fixed combination with prednisolone acetate: 15–25°C.^d Do not freeze; avoid excessive heat (≥40°C).^d

Actions and SpectrumActions

• 
  

  Usually bactericidal in action.^a

  
  


• 
  

  Mechanism of action not fully elucidated; however, appears to inhibit protein synthesis in susceptible bacteria by irreversibly binding to 30S ribosomal subunits.^a

  
  


• 
  

  Active against many aerobic gram-negative and some aerobic gram-positive bacteria.^{a b c} Inactive against fungi, viruses, and most anaerobic bacteria.^a

  
  


• 
  

  Natural and acquired resistance to gentamicin demonstrated in both gram-negative and gram-positive bacteria.^a Resistance to other aminoglycosides and several other anti-infectives (e.g., chloramphenicol, sulfonamides, tetracycline) may be transferred on the same plasmid.^a

  
  


• 
  

  Partial cross-resistance between gentamicin and other aminoglycosides.^a

  
  

Advice to Patients

• 
  

  Importance of removing soft contact lenses prior to administering preparations containing benzalkonium chloride and of delaying reinsertion of the lenses for ≥5 minutes after administration.^f

  
  


• 
  

  Importance of not touching tip of container to the eye, eyelid, fingers, or any other surface to avoid contamination.^{a b c}

  
  


• 
  

  Importance of discontinuing therapy and contacting clinician if the infection worsens or does not improve, or if any signs of sensitivity occur (discharge, swelling, pain).^{b c}

  
  


• 
  

  Advise patient not to share the drug with any other person.^d

  
  


• 
  

  Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.^{b c}

  
  


• 
  

  Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.^{b c}

  
  


• 
  

  Importance of informing patients of other important precautionary information. (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Gentamicin Sulfate

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Ophthalmic	Ointment	0.3% (of gentamicin)	Gentak (with parabens)	Akorn
			Gentamicin Sulfate	Fougera
	Solution	0.3% (of gentamicin)*	Gentak (with benzalkonium chloride)	Akorn
			Gentamicin Sulfate	Bausch & Lomb, Falcon

Gentamicin Sulfate and Prednisolone Acetate

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Ophthalmic	Ointment	Gentamicin Sulfate 0.3% (of gentamicin) and Prednisolone Acetate 0.6%	Pred-G (with chlorobutanol 0.5%)	Allergan
	Suspension	Gentamicin Sulfate 0.3% (of gentamicin) and Prednisolone Acetate 1%	Pred-G (with benzalkonium chloride; viscous)	Allergan

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Gentak 0.3% Ointment (AKORN): 3/$21.99 or 7/$35.98

Gentamicin Sulfate 0.3% Solution (FALCON PHARMACEUTICALS): 5/$25.99 or 10/$45.98

Pred-G 0.3-1% Suspension (ALLERGAN): 5/$39.35 or 15/$101.19

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions August 2008. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

101. Akorn. Gentamicin sulfate ophthalmic solution USP, 0.3% prescribing information. Buffalo Grove, IL; 2002 Jan.

102. Akorn. Gentamicin sulfate ophthalmic ointment USP, 0.3% prescribing information. Somerset, NJ; 1998 Jul.

103. Allergan. Pred-G (gentamicin and prednisolone acetate ophthalmic suspension, USP) 0.3%/1% prescribing information. In: Physicians’ desk reference for ophthalmic medicines. 34th ed. Montevale, NJ: Thomson PDR; 2006: 234-5.

104. American Academy of Ophthalmology. Preferred Practice Pattern: Conjunctivitis. 2003. From the American Academy of Ophthalmology website (http://www.aao.org) Accessed 11 May 2006.

a. AHFS drug information 2008. McEvoy, GK, ed. Gentamicin sulfate (ophthalmic). Bethesda, MD: American Society of Health-System Pharmacists; 2008:2845-6.

b. Akorn, Inc. gentamicin sulfate ophthalmic ointment USP 0.3% prescribing information. Buffalo Grove, IL; 2008 Feb.

c. Akorn, Inc. Gentamicin sulfate ophthalmic solution USP 0.3% prescribing information. Buffalo Grove, IL; 2006 Oct.

d. Allergan, Inc. Pred-G (gentamicin and prednisolone acetate) ophthalmic suspension USP 0.3%/1.0% prescribing information. Irvine, CA; 2005 Dec.

e. Allergan, Inc. Pred-G (gentamicin and prednisolone acetate) ophthalmic ointment USP 0.3%/0.6% prescribing information. Irvine, CA; 2004 Jan.

f. Christensen MT, Barry JR, Turner FD. Five-minute removal of soft lenses prevents most absorption of a topical ophthalmic solution. CLAO J. 1998; 24:227-231. [PubMed 9800062]

g. Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and lactation, 7th ed. Lippincott Williams & Wilkins: Philadelphia, PA; 2005:720-22.

More Gentamicin Sulfate eent resources

• Gentamicin Sulfate eent Use in Pregnancy & Breastfeeding
• Gentamicin Sulfate eent Support Group
• 0 Reviews for Gentamicin Sulfate eent - Add your own review/rating

Compare Gentamicin Sulfate eent with other medications

• Conjunctivitis, Bacterial

Gentasol

Generic Name: gentamicin ophthalmic (JEN ta MYE sin off THAL mik)

Brand Names: Garamycin Ophthalmic, Gentak, Gentasol, Ocu-Mycin

What is Gentasol (gentamicin ophthalmic)?

Gentamicin ophthalmic is an antibiotic.

Gentamicin ophthalmic is used to treat bacterial infections of the eyes.

Gentamicin ophthalmic may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Gentasol (gentamicin ophthalmic)?

Do not touch the dropper or tube opening to any surface, including your eyes or hands. The dropper or tube opening is sterile. If it becomes contaminated, it could cause an infection in your eye.

Apply light pressure to the inside corner of your eye (near your nose) after each drop to prevent the fluid from draining down your tear ducts.

Who should not use Gentasol (gentamicin ophthalmic)?

Do not use gentamicin ophthalmic if you have a viral or fungal infection in your eye. It is used to treat infections caused by bacteria only. It is not known whether gentamicin ophthalmic will harm an unborn baby. Do not use gentamicin ophthalmic without first talking to your doctor if you are pregnant. It is also not known whether gentamicin ophthalmic passes into breast milk. Do not use gentamicin ophthalmic without first talking to your doctor if you are breast-feeding a baby.

How should I use Gentasol (gentamicin ophthalmic)?

Use gentamicin ophthalmic eyedrops or ointment exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before using the eyedrops or ointment.

To apply the eyedrops:

• 
  

  Shake the drops gently to be sure the medicine is well mixed. Tilt your head back slightly and pull down on your lower eyelid. Position the dropper above your eye. Look up and away from the dropper. Squeeze out a drop and close your eye. Apply gentle pressure to the inside corner of your eye (near your nose) for about 1 minute to prevent the liquid from draining down your tear duct. If you are using more than one drop in the same eye or drops in both eyes, repeat the process with about 5 minutes between drops.

  
  

To apply the ointment:

• 
  

  Hold the tube in your hand for a few minutes to warm it up so that the ointment comes out easily. Tilt your head back slightly and pull down gently on your lower eyelid. Apply a thin film of the ointment into your lower eyelid. Close your eye and roll your eyeball around in all directions for 1 to 2 minutes. If you are applying another eye medication, allow at least 10 minutes before the next application.

  
  

Do not touch the dropper or tube opening to any surface, including your eyes or hands. The dropper or tube opening is sterile. If it becomes contaminated, it could cause an infection in your eye. Do not use any eyedrop that is discolored or has particles in it. Store gentamicin ophthalmic at room temperature away from moisture and heat. Keep the bottle or tube properly capped.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

An overdose of this medication is unlikely to occur. If you do suspect an overdose, wash the eye with water and call an emergency room or poison control center near you. If the drops or ointment have been ingested, drink plenty of fluid and call an emergency center for advice.

What should I avoid while using Gentasol (gentamicin ophthalmic)?

Use caution when driving, operating machinery, or performing other hazardous activities. Gentamicin ophthalmic may cause blurred vision. If you experience blurred vision, avoid these activities.

If you wear contact lenses, ask your doctor if you should wear them during treatment. After applying this medication, wait at least 15 minutes before inserting contact lenses, unless otherwise directed by your doctor.

Do not use other eye drops or medications during treatment with gentamicin ophthalmic unless otherwise directed by your doctor.

Gentasol (gentamicin ophthalmic) side effects

Serious side effects are not expected to occur during treatment with this medication.

Commonly, some eye burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Gentasol (gentamicin ophthalmic)?

Do not use other eye drops or medications during treatment with gentamicin ophthalmic unless otherwise directed by your doctor.

Drugs other than those listed here may also interact with gentamicin ophthalmic. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Gentasol resources

• Gentasol Side Effects (in more detail)
• Gentasol Use in Pregnancy & Breastfeeding
• Gentasol Support Group
• 0 Reviews for Gentasol - Add your own review/rating

• Gentasol Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Gentasol Advanced Consumer (Micromedex) - Includes Dosage Information


• Gentak Prescribing Information (FDA)


• Gentak eent Monograph (AHFS DI)


• Gentak Cream MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Gentasol with other medications

• Conjunctivitis, Bacterial

Where can I get more information?

• Your pharmacist has additional information about gentamicin ophthalmic written for health professionals that you may read.

See also: Gentasol side effects (in more detail)